n, pl  -do*ses   :  any of several metabolic disorders that are marked by the accumulation of glycosaminoglycans and lipids in tissues and by lysosomal enzymes which are produced in deficient amounts or which fail to be incorporated into lysosomes, that are inherited as autosomal recessive traits, and that have characteristics (as mental retardation) resembling Hurler's syndrome .
 
 
 
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