Let·ter·er-Si·we disease
n : an acute disease of children characterized by fever, hemorrhages, and other evidences of a disturbance in the reticuloendothelial system and by severe bone lesions esp. of the skull Letterer, Erich (b 1895), German physician. Letterer first described Letterer-Siwe disease in 1924. The author of several textbooks on pathology, he described the disease from the viewpoint of a pathologist. Siwe, Sture August (b 1897), Swedish pediatrician. Siwe presented another, independent description of Letterer-Siwe disease in 1933, this time from the clinical point of view.
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